Journal: The Analyst

Article Title: Deep learning for FTIR histology: leveraging spatial and spectral features with convolutional neural networks

doi: 10.1039/c8an01495g

Figure Lengend Snippet: 3D plot of confusion matrices obtained for all independent test pixels in the HD (1.1 μm) microarray image data using SVM (a) and CNN (b) classifiers.

Article Snippet: Tissue microarrays Four serial sections of formalin fixed paraffin embedded breast tissue microarray (TMA) cores were obtained from Biomax US, Rockville, MD (TMA IDs: BR1003, BR2085b, BR961, and BR1001).

Techniques: Microarray

Journal: The Analyst

Article Title: Deep learning for FTIR histology: leveraging spatial and spectral features with convolutional neural networks

doi: 10.1039/c8an01495g

Figure Lengend Snippet: HD classification using a convolutional neural network with both spectral and spatial features. (a) FTIR validation microarray (11 557 × 17 000 pixels) showing the Amide I (1650 cm−1) absorption band. (b) Classified cores labeled using a false-color overlay on the Amide I absorbance band. Individual classified cores are shown in false-color (c and e) with corresponding images H&E stained adjacent sections (d and f ). H&E images are labeled with cell types of interest, annotated using additional immunohistochemical stains of adjacent sections.

Article Snippet: Tissue microarrays Four serial sections of formalin fixed paraffin embedded breast tissue microarray (TMA) cores were obtained from Biomax US, Rockville, MD (TMA IDs: BR1003, BR2085b, BR961, and BR1001).

Techniques: Biomarker Discovery, Microarray, Labeling, Staining, Immunohistochemical staining

Journal: Cell Death & Disease

Article Title: Manganese superoxide dismutase promotes anoikis resistance and tumor metastasis

doi: 10.1038/cddis.2013.20

Figure Lengend Snippet: Expression of MnSOD in human breast cancer. ( a ) Migrating cancer cells (indicated by arrows) show stronger MnSOD staining than tumor cells in primary tumor mass (upper left corner). ( b ) A small cluster of tumor cells (micrometastasis) in lymph node (right) exhibits higher MnSOD expression than cells in matched primary tumor (left). ( c ) Tumor cells in established lymph-node macrometastasis (right) display increased MnSOD expression compared with those in matched primary tumor (left)

Article Snippet: Formalin-fixed paraffin-embedded human breast cancer sections were deparaffinized, rehydrated, and stained with primary antibodies (1 : 500, anti-MnSOD2 sc-30080; Santa Cruz, Dallas, TX, USA).

Techniques: Expressing, Staining